Tear Film Break up time (TBUT) in allergic papillary conjunctivitis and immediate effect of carboxy methylcellulose on TBUT

  • Dr. Rathnamma Jarmale Assistant Professor, Department of Ophthalmology, Subbaiah Institute of Health Sciences, Purule, Shimoga, Karnataka, India
  • Dr. Vidhya Mysore Jagadeeshwara Assistant Professor, Department of Ophthalmology, Subbaiah Institute of Health Sciences, Purule, Shimoga, Karnataka, India
Keywords: Allergic papillary conjunctivitis, TBUT, Topical carboxymethylcellulose

Abstract

Purpose: To find out the effect of papillae due to allergic conjunctivitis on the tear film break up time (TBUT) and immediate effect of topical carboxymethyl cellulose (CMC) on TBUT in these patients.

Methods: 62 eyes of the 31 patients in the age group of 20-40 years with papillae in the tarsal conjunctiva due to allergic conjunctivitis were subjected to measurement of TBUT. This was followed by application of one drop of 0.5% carboxy methylcellulose eye drop and TBUT was repeated after 5 minutes. Patients not in the 20-40-year age group, presence of any ocular surface disorder, mebomian gland dysfunction and lagophthalmos were excluded from the study.

Results: 31 patients (62 eyes) were included in the study. TBUT was less than 15secs in 47 eyes (75.80%) and more than 15sec in 15eyes (24.19%). TBUT improved after application of topical CMC in 23 eyes (37.09%) and reduced in 21 eyes (33.87%) and remained the same in 18 eyes (29.56%). Percentage of patients who showed improvement in TBUT who had less than normal TBUT was 40.42%. Percentage of patients who showed reduction in TBUT with normal TBUT was 66.66%.

Conclusion: TBUT is less than normal in around two third of the patients with allergic papillary conjunctivitis. Immediate effect of topical CMC showed no significant changes in the TBUT. Topical CMC drops showed better improvement in TBUT in patients with initial reduced TBUT rather than in patients with normal initial TBUT.

Downloads

Download data is not yet available.

References

Phadatare SP, Momin M, Nighojkar P, Askarkar S, Singh KK. A comprehensive review on dry eye disease: Diagnosis, medical management, recent developments and future challenges. Advan Pharmaceut.2015. doi: http://dx.doi.org/10.1155/2015/704946.

Fujishima H, Toda I, Shimazaki J. Allergic conjunctivitis and dry eye. Br J Ophthalmol. 1996;80(11):994-997. doi: http://dx.doi.org/10.1136/bjo.80.11.994.

Suzuki, Shintaro MD,Goto. Tear film lipid layer alteration in allergic conjunctivitis. J Cornea Ext Dis. 2006;25(3):277-280.doi: https://doi.org/10.1097/01.ico.0000178277.29010.bc.

Dogru M, Katakami C, Nakagawa N. Impression cytology in atopic dermatitis. Ophthalmol. 1998:105(8):1478-1484. doi: https://doi.org/10.1016/S0161-6420(98)98032-0.

Dogru M, Okada N, Asano Kato N. Atopic ocular surface disease:Implication on tear function and ocular surface mucin . Cornea. 2005;24(8):518-523.doi: https://doi.org/10.1097/01.ico.0000178741.14212.53.

Garrett Q, Simmons PA, Xu S, Vehige J, Zhao Z, Ehrmann K et al. Carboxymethylcellulose binds to human corneal epithelial cells and is a modulator of corneal epithelial wound healing. Investi Ophthalmol Vis Sci. 2007,48:1559-1567.doi: https://doi.org/10.1167/iovs.06-0848.

Andrea Leonardi, Anthony Hall. Mechanisms of corneal allergic reaction: New options for treatment. Expert Rev Ophthalmol. 2010;5(4):545-556.

Osmo Kari, K Matti Saari. Updates in the treatment of ocular allergies. J Asthma Allergy. 2010:3:149-158. doi: https://doi.org/10.2147/JAA.S13705.

Julie. M. Albietz, Adrian. S. Bruce. The conjunctival epithelium in dry eye subtypes: effect of preserved and non-preserved topical treatments. Current Eye Res. 2009;22(1):8-18.doi: https://doi.org/10.1076/ceyr.22.1.8.6977.

Dogru M, Ozmen A, Erturk H. Changes in tear function and the ocular surface after topical olopatidine treatment for allergic conjunctivitis: an open case study. Clinic Therapeut. 2002;24(8):1309-1321. doi: https://doi.org/10.1016/S0149-2918(02)80035-2.

Lee JH, Ahn HS, Kim E, Kim T. Efficacy of sodium hyaluronate and carboxymethylcellulose in treating mild to moderate dry eye disease. Cornea: 2011;30(2):175-179. doi: https://doi.org/10.1097/ICO.0b013e3181e9adcc.

Yao K, Boa Y, Yang J, Lu Y. Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicentre, open label randomized, controlled study. BMC Ophthalmol. 2015;15:28.doi: https://doi.org/10.1186/s12886-015-0005-3.

Peter AS, Joseph V. Clinical performance of a mid-viscosity artificial tear for dry eye treatment. Cornea. 2007;26(3):294-302. doi: https://doi.org/10.1097/ICO.0b013e31802e1e04.

CITATION
DOI: 10.17511/jooo.2019.i07.01
Published: 2019-11-30
How to Cite
Jarmale, R., & Mysore Jagadeeshwara, V. (2019). Tear Film Break up time (TBUT) in allergic papillary conjunctivitis and immediate effect of carboxy methylcellulose on TBUT. Tropical Journal of Ophthalmology and Otolaryngology, 4(7), 403-408. https://doi.org/10.17511/jooo.2019.i07.01
Section
Original Article