Age related hearing loss- A review
Keywords:
Age-related hearing loss, Cochlea, Presbycusis, Spiral ganglion neuron
Abstract
Age-related hearing loss (ARHL), or presbycusis, is a complex degenerative sickness that influences a huge number of elderly individuals all through the world.ARHL leads to bilaterally symmetrical hearing loss resulting from the aging process. With the growing number of geriatric patients the problem of ARHL needs to be addressed. We herein present a detailed review of this disorder that is affecting the elderly population and is second only to arthritis.
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References
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2. Lee K-Y. Pathophysiology of Age-Related Hearing Loss (Peripheral and Central).Korean J Audiol. 2013;17(2):45-49. [PubMed]
3. Bielefeld EC, Tanaka C, Guang-di Chen, Henderson D. Age-related hearing loss: Is it a preventable condition? Hear Res. 2010;264(1-2):98–107. [PubMed]
4. Gopinath B, Rochtchina E, Wang JJ, Schneider J, Leeder SR, Mitchell P. Prevalence of age-related hearing loss in older adults: Blue Mountains Study. Arch Intern Med. 2009;169:415–416. [PubMed]
5. Kidd AR, Bao J. Recent advances in the study of age-related hearing loss - A Mini-Review. Gerontology. 2012;58(6):490–496. [PubMed]
6. Schuknecht HF, Gacek MR. Cochlear pathology in presbycusis. Ann OtolRhinolLaryngol1993;102:1–16. [PubMed]
7. Kalayam B, Meyers BS, Kakuma T, Alexopoulos GS, Young RC, Solomon S, et al. Age at onset of geriatric depression and sensorineural hearing deficits. Biol Psychiatry 1995;38:649–658. [PubMed]
8. Adams PF, Marano MA. Current estimates from the National Health Interview Survey, 1994. Vital Health Stat 10. 1995;193(pt 1):1–260.
9. U.S. Census Bureau. Table2a: projected population of the United States, by age and sex: 2000 to 2050. The Bureau. Available from URL:- http://www.census.gov/population/www/projecgtions/usinterimproj/natprojtab02a .pdf.Accessed20 May, 2016. [PubMed]
10. Cruickshanks KJ, Wiley TL, Tweed TS, Klein BE, Klein R, Mares-Perlman JA, et al. Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study. Am J Epidemiol. 1998;148:879-86. [PubMed]
11. Gates GA, Couropmitree NN, Myers RH. Genetic associations in age-related hearing thresholds.Archives of Otolaryngology, Head & Neck Surgery. 1999;125(11):654–659.
12. Gates GA, Schmid P, Kujawa SG, Nam B, D’Agostino R. Longitudinal threshold changes in older men with audiometric notches. Hear Res. 2000;141:220–228. [PubMed]
13. Kujawa SG, Liberman MC. Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci. 2006;26:2115–2123. [PubMed]
14. Kujawa SG, Liberman MC: Adding insult to injury. cochlear nerve degeneration after ‘temporary’ noise-induced hearing loss. J Neurosci. 2009;29:14077–14085.
15. Lin HW, Furman AC, Kujawa SG, Liberman MC. Primary neural degeneration in the guinea pig cochlea after reversible noise-induced threshold shift. J Assoc Res Otolaryngol. 2011;12:605–616.
16. Bao J, Ohlemiller KK. Age-related loss of spiral ganglion neurons. Hear Res. 2010;264:93–97. [PubMed]
17. Takeno S, Wake M, Mount RJ, Harrison RV. Degeneration of spiral ganglion cells in the chinchilla after inner hair cell loss induced by carboplatin.AudiolNeurootol. 1998;3:281–290. [PubMed]
18. Fritzsch B, Fariñas I, Reichardt LF. Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion. J Neurosci. 1997;17:6213–6225. [PubMed]
19. Ryals BM, Westbrook EW. Ganglion cell and hair cell loss in Coturnix quail associated with aging. Hear Res. 1988;36:1–8. [PubMed]
20. White JA, Burgess BJ, Hall RD, Nadol JB. Pattern of degeneration of the spiral ganglion cell and its processes in the C57BL/6J mouse. Hear Res. 2000;141:12–18. [PubMed]
21. Linthicum FH, Fayad JN. Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans. OtolNeurotol. 2009;30:418–422. [PubMed]
22. Kokotas H, Petersen MB, Willems PJ. Mitochondrial deafness.ClinGenet. 2007;71:379–391. [PubMed]
23. Someya S, Prolla TA. Mitochondrial oxidative damage and apoptosis in age-related hearing loss.Mech Ageing Dev. 2010;131:480–486. [PubMed]
24. Kujoth GC, Bradshaw PC, Haroon S, Prolla TA. The role of mitochondrial DNA mutations in mammalian aging.PLoSGenet. 2007;23;3:e24. [PubMed]
25. Lévêque M, Marlin S, Jonard L, Procaccio V, Reynier P, Amati-Bonneau P, et al. Whole mitochondrial genome screening in maternally inherited non-syndromic hearing impairment using a microarray resequencing mitochondrial DNA chip. Eur J Hum Genet. 2007;15:1145–1155.
26. Finkel T. Signal transduction by reactive oxygen species. J Cell Biol. 2011;194:7–15.
27. Cui H, Kong Y, Zhang H. Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct. 2012;2012:646354. [PubMed]
28. Van Eyken E, Van Camp G, Van Laer L. The complexity of age-related hearing impairment: contributing environmental and genetic factors. AudiolNeurootol. 2007;12:345–358. [PubMed]
29. Ateş NA, Unal M, Tamer L, Derici E, Karakaş S, Ercan B, et al. Glutathione S-transferase gene polymorphisms in presbycusis. OtolNeurotol. 2005;26:392–397. [PubMed]
30. McFadden SL, Ding D, Reaume AG, Flood DG, Salvi RJ. Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. NeurobiolAging. 1999;20:1–8.
31. Keithley EM, Canto C, Zheng QY, Wang X, Fischel-Ghodsian N, Johnson KR. Cu/Zn superoxide dismutase and age-related hearing loss. Hear Res. 2005;209:76–85.
32. Ohlemiller KK, McFadden SL, Ding DL, Lear PM, Ho YS. Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol. 2000;1:243–254.
33. Heman-Ackah SE, Juhn SK, Huang TC, Wiedmann TS. A combination antioxidant therapy prevents age-related hearing loss in C57BL/6 mice. Otolaryngol Head Neck Surg. 2010;143:429–434.
34. Seidman MD. Effects of dietary restriction and antioxidants on presbyacusis. Laryngoscope. 2000;110:727–738. [PubMed]
35. Bielefeld EC, Coling D, Chen G-D, Li M, Tanaka C, Hu BH, et al. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear Res.2008;241:26–33.
36. Bielefeld EC, Coling D, Chen G-D, Henderson D. Multiple dosing strategies with acetyl l-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat. J Negat Results Biomed. 2008;7:4. [PubMed]
37. Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla TA, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res.2007;226:185–193. [PubMed]
38. Crawley BK, Keithley EM. Effects of mitochondrial mutations on hearing and cochlear pathology with age. Hear Res. 2011;280:201–208. [PubMed]
39. Someya S, Yamasoba T, Kujoth GC, Pugh TD, Weindruch R, Tanokura M, et al. The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.Neurobiol Aging. 2008;29:1080–1092. [PubMed]
40. Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. NeurobiolAging. 2007;28:1613–1622.
41. Feuers RJ. The effects of dietary restriction on mitochondrial dysfunction in aging. Ann N Y AcadSci. 1998;854:192–201. [PubMed]
42. Jókay I, Soós G, Répássy G, Dezsõ B. Apoptosis in the human inner ear. Detection by in situ end-labeling of fragmented DNA and correlation with other markers. Hear Res. 1998;117:131–139. [PubMed]
43. Tadros SF, D’Souza M, Zhu X, Frisina RD. Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis. 2008;13:1303–1321.
44. Niu X, Trifunovic A, Larsson N-G, Canlon B. Somatic mtDNA mutations cause progressive hearing loss in the mouse. Exp Cell Res.2007;313:3924–3934. [PubMed]
45. Wang J, Menchenton T, Yin S, Yu Z, Bance M, Morris DP, et al. Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice. NeurobiolAging. 2010;31:1238–1249. [PubMed]
46. Sha S-H, Chen F-Q, Schacht J. Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hear Res. 2009;254:92–99.
47. Shen H, Matsui JI, Lei D, Han L, Ohlemiller KK, Bao J. No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice. MolNeurodegener. 2010;5:28. [PubMed]
48. Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, et al. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. ProcNatlAcadSciUSA. 2009;106:19432–19437. [PubMed]
49. Buchholz JN, Behringer EJ, Pottorf WJ, Pearce WJ, Vanterpool CK.Age-dependent changes in Ca2+ homeostasis in peripheral neurones: implications for changes in function. Aging Cell. 2007;6:285–296. [PubMed]
50. Toescu EC, Verkhratsky A, Landfield PW. Ca2+ regulation and gene expression in normal brain aging. Trends Neurosci. 2004;27:614–620. [PubMed]
51. Idrizbegovic E, Bogdanovic N, Willott JF, Canlon B. Age-related increases in calcium-binding protein immunoreactivity in the cochlear nucleus of hearing impaired C57BL/6J mice. NeurobiolAging. 2004;25:1085–1093. [PubMed]
52. Mills JH, Matthews LJ, Lee FS, Dubno JR, Schulte BA, Weber PC. Gender-specific effects of drugs on hearing levels of older persons. Ann N Y AcadSci.1999;884:381–388. [PubMed]
53. Lee S, Briklin O, Hiel H, Fuchs P. Calcium-dependent inactivation of calcium channels in cochlear hair cells of the chicken. J Physiol (Lond). 2007;583:909–922. [PubMed]
54. Lopez I, Ishiyama G, Acuna D, Ishiyama A, Baloh RW. Immunolocalization of voltage-gated calcium channel alpha1 subunits in the chinchilla cochlea. Cell Tissue Res. 2003;313:177–186. [PubMed]
55. Shen H, Zhang B, Shin J-H, Lei D, Du Y, Gao X, et al. Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. Hear Res. 2007;226:52–60. [PubMed]
56. Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, et al. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature. 1998;391:896–900. [PubMed]
57. Lei D, Gao X, Perez P, Ohlemiller KK, Chen C-C, Campbell KP, et al. Anti-epileptic drugs delay age-related loss of spiral ganglion neurons via T-type calcium channel. Hear Res. 2011;278:106–112. [PubMed]
58. Shen H, Lin Z, Lei D, Han J, Ohlemiller KK, Bao J. Old mice lacking high-affinity nicotine receptors resist acoustic trauma. Hear Res. 2011;277:184–191. [PubMed]
59. Bao J, Lei D, Du Y, Ohlemiller KK, Beaudet AL, Role LW. Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging. J Neurosci. 2005;25:3041–3045.
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CITATION
DOI: 10.17511/jooo.2016.i01.05
Published: 2016-12-31
How to Cite
Yadav, S., & Rawal, G. (2016). Age related hearing loss- A review. Tropical Journal of Ophthalmology and Otolaryngology, 1(1), 17-24. https://doi.org/10.17511/jooo.2016.i01.05
Section
Review Article
Copyright (c) 2016 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
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