Chloroma of the orbit as a presenting feature of acute myeloid leukemia in a four year old female child
Abstract
A four year old female child presented with a painless swelling of the right lower lid for 25days, which was progressively increasing in size. On palpation, a firm nodular mass just above the inferior orbital margin was noted. MRI showed homogenous enhancing mass in the orbit. Progressive axial proptosis developed in 8 days, with inability to close the eye. Bone marrow aspiration at this stage revealed Acute Myeloid Leukemia. Chemotherapy was started. Bone marrow picture after 10days showed remission phase. Symptoms and signs began to regress. The child was discharged on maintenance chemotherapy; but was admitted 3weeks later with fever; the child expired after admission 2 days due to secondary infection.
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References
2. Ooi GC, Chim CS, Khong PL, et al. Radiologic manifestations of granulocytic sarcoma in adult leukemia. DOI:10.2214/ajr.176.6.1761427AJR Am J Roentgenol. 2001 Jun;176(6):1427-31.
3. Reese AB, Guy L. Amer J Ophthal-1933;16:671.
4. Guermazi A, Feger C, Rousselot P, et al. Granulocytic sarcoma (chloroma): imaging findings in adults and children. DOI:10.2214/ajr.178.2.1780319AJR Am J Roentgenol. 2002 Feb;178(2):319-25.
5. Lee SG, Park TS, Cheong JW, et al.Preceding orbital granulocytic sarcoma in an adult patient with acute myelogenous leukemia with t(8;21): a case study and review of the literature. Cancer Genet Cytogenet. 2008 Aug;185(1):51-4.doi:10.1016/j.cancergencyto.2008.04.016.[pubmed]
6. Murthy R, Vemuganti GK, Honavar SG, et al. Extramedullary leukemia in children presenting with proptosis. J Hematol Oncol. 2009 Jan 24;2:4. doi:10.1186/1756-8722-2-4.[pubmed]
7. Alkatan H, Chaudhry I. Myeloid sarcoma of the orbit. Ann Saudi Med. 2008 Nov-Dec;28(6):461-5.[pubmed]
8. Cavdar AO, Arcasoy A, Babacan E, Gözdaolu S, Topuz U, Fraumeni JF Jr. Ocular granulocytic sarcoma (chloroma) with acute myelomonocytic leukemia in Turkish children. Cancer- 1978 Apr; 41(4):1606–09.
9. Uyesugi WY, Watabe J, Petermann G. Orbital and facial granulocytic sarcoma (chloroma): a case report. PediatrRadiol. 2000 Apr;30(4):276-8. doi:10.1007/s002470050740.[pubmed]
10. Sethi A, Ghose S, Gujral S, et al. Childhood proptosis: the invaluable but overlooked peripheral blood smear. Indian J Ophthalmol. 2001 Jun;49(2):121-3.[pubmed]
11. Gupta O, Yadav YK, Dorga S, RangaS. Childhood proptosis: Relevance of aspiration cytology in the era of newer molecular diagnostic and imaging technology. Oman J Ophthalmol- 2012 Aug 4;5(2):128-30.
12. Ansari S, Rauniyar RK, Dhungel K et al. Acute myeloid leukemia presenting as bilateral proptosis and right temporal swelling. Oman J Ophthalmol- 2014;7(1):35-37.
Copyright (c) 2018 Author (s). Published by Siddharth Health Research and Social Welfare Society
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