Epidemiology and demographics of head and neck cancers: a hospital based retrospective study in Andhra Pradesh
Abstract
Background: Head and Neck cancers (HNC) in India make up 25-30 percent of all cancers and are the most common cancer in Indian men and the third most common cancer in women. The aim of this study was to study the demographic profile, sites involved and the histopathological patterns of HNC at a tertiary care hospital in Sri Potti Sriramulu Nellore district, Andhra Pradesh.
Materials and Methods: This was a retrospective study conducted in Department of Otolaryngology, Narayana Medical College and Hospital, SPS Nellore, Andhra Pradesh. The data was collected from the years 2015 to 2018. Only histopathologically confirmed cases of malignancies of Head and Neck were included in the study.
Results: A total of 75 cases were included in the study. There were 53 (70.66%) male and 22 (29.33%) female patients. The mean age of male and female patients was 56.45±11.46 and 51.68±9.20 years respectively. The most common sites HNC, in both male and female patients, were found to be larynx (36%) followed by oral cavity (33.33%). It was also observed that squamous cell carcinoma (SCC) was the most common histopathological variant amongst all the HNC. All the patients in this study had one or more associated risk factors for HNC.
Conclusion: There is a spurt of HNC cases in SPS Nellore. It is important to focus on prevention and early detection of HNC and also have a dedicated cancer hospital to cater the needs of the patients.
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References
Mathers C. The global burden of disease: 2004 update. World Health Organization; 2008.
Reddy KS, Shah B, Varghese C, Ramadoss A. Responding to the threat of chronic diseases in India. The Lancet. 2005;366(9498):1744-1749. doi: https://doi.org/10.1016/S0140-6736(05)67343-6.
India. Office of the Registrar General, University of Toronto. Centre for Global Health Research. Report on Causes of Death in India, 2001-2003. Office of the Registrar General India in collaboration with Centre for Global Health Research, St. Michael's Hospital, University of Toronto; 2009.
Cancer Statistics Available at: http://cancerindia.org.in/cancer-statistics/.
WHO: Global Cancer Observatory, International Agency for Research on Cancer. Available at https://gco.iarc.fr/.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA: A Can J Clinic. 2016;66(1):7-30. doi: 10.3322/caac.21332.
Gatta G, Botta L, Sánchez MJ, Anderson LA, Pierannunzio D, Licitra L, et al. Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: The EUROCARE-5 population-based study. Europe J Cancer. 2015;51(15):2130-2143. doi: https://doi.org/10.1016/j.ejca.2015.07.043.
Asthana S, Patil RS, Labani S. Tobacco-related cancers in India: A review of incidence reported from population-based cancer registries. Indian J Med Paediatr Oncol: J Indian Soc Med Paediatr Oncol. 2016;37(3):152. doi: https://dx.doi.org/10.4103%2F0971-5851.190357.
Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA: Cancer J Clinic. 2017;67(2):122-137. doi: https://doi.org/10.3322/caac.21389.
Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988;48(11):3282-3287.
Guha N, Boffetta P, Wünsch Filho V, Eluf Neto J, Shangina O, Zaridze D, et al. Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. Am J Epidemiol. 2007;166(10):1159-1173. doi: https://doi.org/10.1093/aje/kwm193.
Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Prevent Biomark. 2005;14(2):467-475. doi: https://doi.org/10.1158/1055-9965.EPI-04-0551.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC monographs on the evaluation of carcinogenic risks to humans. 2004; 85:1.
Rekha R, Reddy MV, Reddy PP. Epidemiological studies of head and neck cancer in South Indian Population. Res Cancer Tumor. 2013;2(2):38-44. doi:10.5923/j.rct.20130202.04.
Siddiqui M, Chandra R, Aziz A, Suman S. Epidemiology and histopathological spectrum of head and neck cancers in Bihar, a state of Eastern India. Asian Pacific J Cancer Prevent. 2012;13(8):3949-3953. doi: https://doi.org/10.7314/APJCP.2012.13.8.3949.
Dasgupta S, Chakrabarti S, Deb AR. Clinicopathological profile of head and neck squamous cell carcinoma. Indian J Med Paediatr Oncol. 2019;40(3):369-373. doi: https://doi.org/10.4103/ijmpo.ijmpo_180_17.
Alam MS, Siddiqui SA, Perween R. Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor. J Cancer Res Therapeut. 2017;13(3):430. doi: https://doi.org/10.4103/0973-1482.180687.
Bhattacharjee A, Chakraborty A, Purkaystha P. Prevalence of head and neck cancers in the north east—an institutional study. Indian J Otolaryngol Head Neck Surg. 2006;58(1):15-19. doi: https://doi.org/10.1007/BF02907731.
Shunyu NB, Syiemlieh J. Prevalence of head and neck cancer in the state of Meghalaya: Hospital-based study. Int J Head Neck Surg. 2013;4(1):1-5.
Pai SI, Westra WH. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Ann Rev Pathol: Mec Dis. 2009; 4:49-70. doi: https://doi.org/10.1146/annurev.pathol.4.110807.092158.
Pathak J, Swain N, Patel S, Poonja LS. Histopathological variants of oral squamous cell carcinoma-institutional case reports. J Oral Maxillofac Pathol: JOMFP. 2014;18(1):143. doi: https://dx.doi.org/10.4103%2F0973-029X.131945.
Forastiere A, Koch W, Trotti A, Sidransky D. Head and neck cancer. New Eng J Med. 2001;345(26):1890-900. doi: https://doi.org/10.1056/NEJMra001375.
Mehrotra R, Singh M, Gupta RK, Singh M, Kapoor AK. Trends of prevalence and pathological spectrum of head and neck cancers in North India. Indian J Cancer. 2005;42(2):89. doi: https://doi.org/10.4103/0019-509X.16698.
Cohen N, Fedewa S, Chen AY. Epidemiology and demographics of the head and neck cancer population. Oral Maxillofac Surg Clinic. 2018;30 (4):381-395. doi: https://doi.org/10.1016/j.coms.2018.06.001.
Hoffmann D, Hecht SS, Ornaf RM, Wynder EL, Tso TC. Chemical studies on tobacco smoke. XLII. Nitrosonornicotine: presence in tobacco, formation and carcinogenicity. IARC scientific publications. 1976;(14):307-320.
IARC Working Group. (2012). Consumption of alcoholic beverages. Lyon: International Agency for Research on Cancer.
Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nature Rev Cancer. 2007;7(8):599. doi: https://doi.org/10.1038/nrc2191.
Garro AJ, Espina N, Farinati F, Salvagnini M. The effects of chronic ethanol consumption on carcinogen metabolism and on O6‐methylguanine transferase‐mediated repair of alkylated DNA. Alcoholism: Clinic Experiment Res. 1986;10(6):73S-77S.
Seitz H. K., Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chemi. 2006;387(4):349-360. doi: https://doi.org/10.1515/BC.2006.047.
Wagner S, Sharma SJ, Wuerdemann N, Knuth J, Reder H, Wittekindt C, Klussmann JP. Human papillomavirus-related head and neck Cancer. Oncol Res Treat. 2017;40(6):334-340. doi: https://doi.org/10.1159/000477252.
Dandekar M, Tuljapurkar V, Dhar H, Panwar A, D Cruz AK. Head and neck cancers in India. J Surg Oncol. 2017;115(5):555-563. doi: https://doi.org/10.1002/jso.24545.
Nellore City Census 2011 data Available at https://www.census2011.co.in/census/city/416-nellore.html
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