TY - JOUR AU - Anchal Tripathi AU - RC Gupt AU - Shalini Mohan PY - 2022/01/12 Y2 - 2024/03/29 TI - Can Myopia Be Reversed? - A Study on the Role of Atropine Eye drops in Arresting Myopia Progression JF - Tropical Journal of Ophthalmology and Otolaryngology JA - Trop j ophthalmol otolaryngol VL - 6 IS - 6 SE - Original Article DO - UR - https://opthalmology.medresearch.in/index.php/jooo/article/view/217 AB - Purpose: To investigate the effect of atropine in retarding progression of myopia.To compare rates of retardation of myopia progression using 0.05% atropine and 0.1% atropine. Methods:This is a hospital based prospective study. Patients were selected from children, between 6-18 yrs of age, visiting the outpatient department of our hospital, with spherical equivalent (SE) =>-1D in both the eyes (with spherical equivalent (SE) progression rate >= 0.5D/year). Groups with 0.05% atropine eyedrops, 0.1% atropine eyedrops and control were allocated randomly. Myopia progression was measured by change in spherical equivalent and axial length at baseline and every 3 months till 1 year. Results: In our study, a total of 48 eyes of 24 children were included, out of which 83.33% were in age group 6-12years; rest in 13-18years age group. The mean change in spherical equivalent in our study after one year was -0.72±0.21D, -0.11±0.096D and -0.19±0.18D in placebo, 0.1% and 0.05% atropine groups respectively. Also, the mean change in axial length our study after one year was 0.45±0.15mm, 0.13±0.20mm and 0.11±0.02mm in placebo, 0.1% and 0.05% atropine groups respectively. Change in both parameters were found to be statistically significant.Conclusion:We conclude that night time  application of 0.05% and 0.1% atropine eyedrops  is efficacious in retarding progressive myopia in Indian eyes. Atropine eyedrops were better tolerated in pre-adolescent children. Drop out rate was more in the adolescent population, which may be due to more amount of near work.KEYWORDS: atropine, axial length, myopia, spherical equivalent ER -